A case of temporal bone fibrous dysplasia causing central venous thrombosis and intracranial hypertension

Fibrous dysplasia is a slowly progressive benign fibro-osseous disorder of unknown cause. The predilection sites of the craniofacial bones are maxilia and mandible, but fibrous dysplasia of the temporal bone is rarely noted, The usual clinical manifestations of fibrous dysplasia of the temporal bone are mainly otologic complications such as progressive stenosis of the external auditory canal and conductive hearing loss. But its neurologic complications are very rarely reported except facial nerve paresis. We present a case of monostotic fibrous dysplasia of the temporal bone leading to intracranial hypertension with central venous thrombosis. To our knowledge, this association has not been previously described in the literature.

A case of acute motor axonal neuropathy associated with IgG GM1 antibody and Campylobacter Jejuni

Guillain-Barre syndrom(GBS) is not a single entity, but may arise from a variety of pathogenic mechanisms. In GBS, abnormally increased autoantibody levels to GM, constitute a group with motor neuropathy predominantly and substantial axonal damage, particularly those following Campylobacter enteritis. We report a patient, 43 years old male, who presented with 3 days history of rapidly progressive weakness of all extremities. Electreophysiologic studies were suggestive of axonal form of motor dominant polyneuropathy, Using ELISA, autoantibody of MAG(myelin associated glycoprtein) and SGPG(sulfoglucuronyl paraglobiside) showed normal ranges, but IgG GM. Autoantibodies abnormally elevated. Additionally antibody titer of Campylobacter jejuni increased. We reported the axonal form of Guillain, Barr syndrome associated with IgG GM,, Ab and antiCampylobacter jejuni antibody.